A dopamina n�o est� sozinha na DP

Emilio Takase, Coordenador do Laborat�rio de Neuroterapia Cognitiva da UFSC. enviou-me um artigo com a noticia de um estudo que tenta provar a rela�ao entre depressao e baixos niveis de serotonina e o aparecimento da DP. Pelo visto a falta de dopamina n�o � uma condi��o �nica e isolada no aparecimento dos sintomas conhecidos como doen�a de parkinson. Mais uma raz�o para a enfase nas caminhadas e outros exercicios que sabidamente mant�m alto o nivel de endorfina e, quem sabe l�, de muitos outros neurotransmissores. Talvez seja por isso que a fisioterapia d� tanta enfase � ativa��o de grupos de m�sculos motores, especialmente aqueles ligados �s principais articula��es (quadril e ombros). A estrat�gia � manter o indiv�duo funcionando: "O grau de alongamento dos extensores da coxa (isquiotibiais) limitam a fun��o dos flexores do quadril."(..)"A musculatura extensora trabalha muito na frenagem do movimento do quadril.
Hiperextens�o do Quadril ou da Coxa." � o que leio numa p�gina de fisioterapia. Da� porque o portador de DP arrasta os p�s e nas topadas vai pro ch�o. De nada adianta uma suplementa��o artificial de neurotransmissores se o c�rebro esqueceu que o m�sculo existe. Portanto, mais uma raz�o para seguir o conselho de Janice: ande!. Pelo amor de Deus.



-----Mensagem Original-----
De: Emilio
Enviado: ter�a-feira, 28 de maio de 2002 15:51
Para: marcilio; LUCIANO P. Stahelin; LUCIANO P. Stahelin
Assunto: Depressed at Risk of Parkinson's Disease


Depressed at Risk of Parkinson's Disease
Health Media Ltd - May 28, 2002

Parkinson's disease patients often suffer from depression and both conditions are associated with low levels of serotonin.
However, it had not been shown that depression could precede the symptoms of Parkinson's. Dr Agnes Schuurman and
colleagues from Maastricht University in the Netherlands questioned whether depression could be the first symptom of
Parkinson's disease. They identified all individuals on a health registry in the southern part of the country who were diagnosed
with depression over a 15-year period. These 1,358 individuals with a history of depression were then matched with 67,570
people in the registry who had been born in the same year but had no history of depression. Dr Schuurman's team followed
these individuals for up to 25 years and recorded the prevalence of Parkinson's disease. Nineteen, or 1.4 per cent, of the
depressed people went on to develop Parkinson's disease, compared to only 259, or 0.4 per cent, of the non-depressed group.
The researchers believe that low serotonin levels are the link between depression and Parkinson's disease. Serotonin acts to
modulate the release of dopamine in the brain and, because dopamine activity is decreased in Parkinson's disease, the
scientists suggest that serotonin activity might also be decreased in compensation. "Because the reduced serotonin activity
already exists before any motor symptoms begin, the risk of depression is also increased long before any Parkinson's
symptoms become apparent," said Dr Schuurman. Reference: Schuurman et al, Neurology 2002;58:1501-1504

To see more focused health-related content, go to http://www.health-news.co.uk

(c) Health Media Ltd 2002