DIFERENCAS ENTRE AS FORMAS DE LEVODOPA (II)
-----Mensagem Original-----
De: Dalva de Paula Molnar
Enviado: quinta-feira, 24 de outubro de 2002 00:21
Para: marciliosantos@hotmail.com
Assunto: .....sinemet.......hugo......

MARCILIO - Tentei enviar um mail para o Hugo, n�o achei o endere�o... se puder envie estes anexos..penso que ele poder� obter alguma informa��o, um deles eu passei no tradutor! - Agrade�o - Dalva
Diet And Sinemet�:
What's The Connection
Have you ever wondered why some medicines work best when taken with meals, others when taken without any food or drink, and still others are unaffected by what or when you eat? One reason is that different medicines are absorbed into your bloodstream in different ways.

Sinemet (carbidopa/levodopa), unlike some other medicines, is not absorbed into the bloodstream from the stomach. It is absorbed from the small bowel after the stomach empties its contents there. Anything that delays the emptying of your stomach into your small bowel can reduce the amount of Sinemet that is absorbed into your blood and transported to your brain. Also, certain foods, such as those that are high in protein, contain substances that actually compete with Sinemet for entry into the brain. When less Sinemet gets to your brain, poor symptom control results.

Because diet can reduce the effectiveness of your Sinemet therapy, doctors sometimes suggest dietary changes that help ensure consistent levels of this medicine in your system. The need for these changes must be evaluated along with the need for a well-balanced diet that allows you to maintain an ideal body weight. For example, to maintain an appropriate level of protein in your diet but keep it from interfering with your medication, your doctor may suggest: (1) restricting your protein intake if it is higher than the recommended daily allowance, (2) distributing it more evenly throughout the day, or (3) restricting it to the evening meal to make sure that you get the full benefit of your medication during the day.

It is especially important to discuss diet with your doctor if you are experiencing changes in the control of your symptoms throughout the day, or if you've noticed that your ability to function seems to be affected when you eat certain foods. These are signs that your diet is interfering with the absorption of your medication, and some adjustments may be needed.

If you are taking Eldepryl� (selegiline hydrochloride) Capsules along with Sinemet, it's helpful to know that there are no specific dietary restrictions associated with taking them at the recommended doses of a 5-mg capsule with breakfast and a 5-mg capsule with lunch. Unlike some similar medicines, Eldepryl Capsules at recommended doses work on one specific enzyme, and are therefore rarely affected by foods that contain a substance called tyramine, like some fermented cheeses and red wines.





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Composition
Sinemet is a combination of Carbidopa, an inhibitor of the aromatic amino-acid decarboxylase enzyme and Levodopa (L-Dopa), the metabolic precursor of Dopamine, and it is used in the treatment of Parkinson's disease and Parkinson's syndrome. Levodopa relieves the symptoms of Parkinson's disease presumably when it becomes decarboxylased to Dopamine in the Brain. Carbidopa, which does not cross the haematoencephalic barrier, is limited to only to the extra cerebral decarboxylation of the Levodopa, thus providing a greater amount of Levodopa to the Brain, for it's subsequent transformation into Dopamine. This eliminates the need for large doses of Levodopa at frequent intervals. The lower dosage, on the other hand, also reduces or eliminates many of the side effects attributed to the Dopamine formed in extra cerebral tissue.
A composi��o Sinemet � uma combina��o de Carbidopa, um inibidor do enzyme aromatic do decarboxylase do amino-acid e Levodopa (L-l-Dopa), o precursor metabolic do dopamine, e s�o usados no tratamento da doen�a de Parkinson e do syndrome de Parkinson. Levodopa alivia os sintomas da doen�a de Parkinson presumably quando se torna decarboxylased ao dopamine no c�rebro. Carbidopa, que n�o cruza a barreira haematoencephalic, � limitado a somente ao decarboxylation cerebral extra do Levodopa, assim fornecendo uma quantidade mais grande de Levodopa ao c�rebro, porque a ele � transforma��o subseq�ente no dopamine. Isto elimina a necessidade para doses grandes de Levodopa com intervalos frequentes. O dosage mais baixo, na outra m�o, tamb�m reduz ou elimina muitos dos efeitos laterais atribu�dos ao dopamine dado forma no tecido cerebral extra.
Used as prescribed and thanks to it's Levodopa content. Sinemet improves general therapeutic response. It's lower dosage (approximately 80% less than that of Levodopa alone), provides effective and lasting plasmatic concentrations of Levodopa. While it is known that pyridoxine hydrochlorate (Vitamin B6), accelerates the periferic metabolism of Levodopa to Dopamine, Carbidopa inhibits this action.
Usado como prescrito e os agradecimentos a ele s�o �ndice de Levodopa. Sinemet melhora a resposta therapeutic geral. � um dosage mais baixo (aproximadamente 80% mais menos do que aquele de Levodopa sozinho), fornece concentra��es plasmatic eficazes e durando de Levodopa. Quando se souber que o hydrochlorate do pyridoxine (vitamina B6), acelera o metabolism periferic de Levodopa ao dopamine, Carbidopa inibe esta a��o.
In an experiment in which patients received from 100 to 500mg of pyridoxine on a daily basis, no alteration was seen in the anti- Parkinson effect of the Levodopa, while they were treated with the Carbidopa and Levodopa combination. It has been reported that the combination of Sinemet with the inhibitors of the Monoamine Oxydase B (such as Deprenyl) increases the effectiveness of Sinemet in patients with difficulty or slowness of movement.
O In uma experi�ncia em que os pacientes receberam de 100 a 500mg do pyridoxine em uma base di�ria, nenhuma altera��o foi visto anti- no efeito de Parkinson do Levodopa, quando foram tratados com a combina��o de Carbidopa e de Levodopa. Relatou-se que a combina��o de Sinemet com os inibidores do Monoamine Oxydase B (tal como Deprenyl) aumenta a efic�cia de Sinemet nos pacientes com dificuldade ou slowness do movimento.
Clinical Advantages
Sinemet usually reduces and in some cases even eliminates side effects frequently suffered by patients undergoing Levodopa therapy- Anorexia, nausea, vomiting. By reducing some of the side effects produced by Levodopa used alone, Sinemet allows a greater number of patients to feel relief from the symptoms of Parkinson's disease.
Sinemet provides fast therapeutic relief. Response to Sinemet has been seen in as little as a day's time, often after a single dose. Sinemet minimizes the need for the prolonged individual dosages required in Levodopa treatment. Fully effective dosages are usually carried out within seven days, in contrast to the weeks or months needed for Levodopa. Following the Sinemet treatment, the plasmatic levels from Levodopa are five times greater than those obtained with the same dosage of Levodopa applied on it's own.
As vantagens cl�nicas Sinemet reduzem-se geralmente e em alguns casos elimina mesmo os efeitos laterais sofridos freq�entemente pelos pacientes que submetem-se ao anorexia da terapia de Levodopa, nausea, vomiting. Reduzindo-se alguns dos efeitos laterais produziram por Levodopa usado sozinho, Sinemet permitem que um n�mero mais grande dos pacientes sinta o relevo dos sintomas da doen�a de Parkinson. Sinemet fornece o relevo therapeutic r�pido. A resposta a Sinemet foi vista dentro t�o pouco quanto o tempo de um dia, frequentemente ap�s um �nico dose. Sinemet minimiza a necessidade para os dosages individuais prolongados requeridos no tratamento de Levodopa. Os dosages inteiramente eficazes s�o realizados geralmente dentro de sete dias, no contraste �s semanas ou aos meses necessitadas para Levodopa. Depois do tratamento de Sinemet, os n�veis plasmatic de Levodopa s�o cinco vezes mais grandes do que aqueles obtidos com o mesmo dosage de Levodopa aplicado nele s�o possuir.
Subjects responding to Levodopa can receive Sinemet treatment. Sinemet reduces the fluctuations, often seen in the use of Levodopa on it's own, in the patient's response. Sinemet may be used with other anti-Parkinson medicine (see directions).
Os assuntos que respondem a Levodopa podem receber o tratamento de Sinemet. Sinemet reduz as flutua��es, vistas frequentemente no uso de Levodopa nele deve possuir, na resposta do paciente. Sinemet pode ser usado com a outra
Information for Users
Sinemet is recommended for the treatment of Parkinson's disease and Parkinson's syndrome. It is very useful for alleviating Parkinson's syndrome, especially stiffness and bradykinesia. Sinemet is often useful in the treatment of tremors, dysphasia, excessive saliva flow and postural instability, associated with Parkinson's disease or syndrome. When therapeutic response to Levodopa by itself is irregular, and the signs and symptoms of Parkinson's disease do not appear in a uniformly controlled manner during the day, the substitution of Sinemet usually proves to be effective in reducing this fluctuation.
By reducing certain side effects produced by the use of Levodopa on it's own. Sinemet enables a greater number of patients to obtain an adequate remission from the symptoms of Parkinson's disease. Sinemet is recommended for patients suffering from Parkinson's disease or syndrome, who have been taking Vitamin complexes containing B6.
A informa��o para usu�rios Sinemet � recomendada para o tratamento da doen�a de Parkinson e do syndrome de Parkinson. � muito �til para aliviar o syndrome, especial a rigidez e a bradicinesia de Parkinson. Sinemet � frequentemente �til no tratamento dos tremors, dysphasia, fluxo excessivo do saliva e instabilidade postural, associada com a doen�a de Parkinson ou o syndrome. Quando a resposta therapeutic a Levodopa por se � irregular, e os sinais e os sintomas da doen�a de Parkinson n�o aparecem em uma maneira uniformemente controlada durante o dia, a substitui��o de Sinemet prova geralmente ser eficaz em reduzir esta flutua��o. Reduzindo determinados efeitos laterais produzidos pelo uso de Levodopa nele � possuir. Sinemet permite um n�mero mais grande dos pacientes de obter um remission adequado dos sintomas da doen�a de Parkinson. Sinemet � recomendado para os pacientes que sofrem da doen�a ou do syndrome de Parkinson, que t�m feito exame dos complexos da vitamina que cont�m B6.

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