Ol� Marc�lio,

Envio abaixo o e-mail onde o Dr Lieberman comenta o trabalho do Dr C�cero. Se a publica��o no Blog puder ser feita via e-mail, por favor me informe como, que publicarei a tradu��o do coment�rio do Dr Lieberman.

Um abra�o,
Cl�udia

-----Mensagem original-----
De: Ask The Doctor
Para: Ask the Doctor
Data: Sexta-feira, 26 de Setembro de 2003 05:47
Assunto: High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in PWP (abstract)


>A message from Ask the Doctor The NPF website is a free service of the National >Parkinson Foundation. If you are helped by the articles >and answers to your questions, please make an >online contribution to the NPF at
>https://www.parkinson.org/reqformv.htm

>Without seeing you and examining you the doctor cannot make specific diagnoses and recommendations. The suggestions given in this forum are for general information only.

>I would appreciate your opinion regarding the following study. Would you advise patients to try out and follow the diet used in this study (no red meat and riboflavin 30 mg, 3x/day), the more since riboflavin (vitamin B2) is cheap, available over the counter without a recipe and there >are no serious side-effects known in people using riboflavin in high doses.
>
>Source: Braz J Med Biol Res. 2003 Oct;36(10):1409-17. Date: Epub 2003 Sep 16. PMID: 14502375
>
>High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients.
>
>Coimbra CG, Junqueira VB.
>
>Setor de Neurologia, Hospital do Servidor Publico Municipal de Sao Paulo, Sao Paulo, SP, Brasil.






>
>Abnormal riboflavin status in the absence of a dietary deficiency was detected in 31 consecutive outpatients with Parkinson's disease (PD), while the classical determinants of homocysteine levels (B6,folic acid, and B12) were usually within normal limits. In contrast, only 3 of 10 consecutive outpatients with dementia without previous stroke had abnormal riboflavin status. The data for 12 patients who did not complete >6 months of therapy or did not comply with the proposed treatment paradigm were excluded from analysis. Nineteen PD patients (8 males >and 11 females, mean age SD = 66.2 8.6 years; 3, 3, 2, 5, and 6 patients in Hoehn and Yahr stages I to V) received riboflavin orally (30 mg every 8 h) plus their usual symptomatic medications and all red meat was eliminated from their diet. After 1 month the riboflavin status of the >patients was normalized from 106.4 34.9 to 179.2 23 ng/ml (N = 9). >Motor capacity was measured by a modification of the scoring system of >Hoehn and Yahr, which reports motor capacity as percent. All 19 patients >who completed 6 months of treatment showed improved motor capacity during the first three months and most reached a plateau while 5/19 continued to improve in the 3- to 6-month interval. Their average motor capacity increased from 44 to 71% after 6 months, increasing significantly every month compared with their own pretreatment >status (P < 0.001, Wilcoxon signed rank test). Discontinuation of riboflavin for several days did not impair motor capacity and yellowish urine was the only side effect observed. The data show that the proposed treatment improves the clinical condition of PD patients. Riboflavin-sensitive mechanisms involved in PD may include glutathione depletion, cumulative mitochondrial DNA mutations, disturbed mitochondrial protein complexes, and abnormal iron metabolism. More studies are required to identify the mechanisms involved.
>
>
>COMMENT

> this is an interesting study that MAY turn out to be important the main problems are it is a small study, the patients were followed a relatively short time, the hoehn and yahr scale is a five point scale and may be too sensitive to change the authors themselves point out additonal studies are needed it is unclear what the contribution of red meat is to pd it is possible if patients were on sinemet or madopar and stopped eating red meat which has a high protein intake that their medications worked better it should also be pointed out that one of the more infamous sufferers with parkinson was adolf hitler who was a vegetarian and a vitamin "freak" this is a study to think about You are currently subscribed to askthedoctor as: cstreva