Marijuana receptor agonist reduces levodopa-induced diskinesias
Nabilone effective in an animal model of Parkinson�s disease (Tuesday, 11 March 2003)
In an animal model of Parkinson�s disease, in which the disease was produced by the administration of the toxin MPTP, the co-administration of nabilone, an agonist i.e. stimulant of cannabinoid receptors, was associated with halving of dyskinesias (involuntary movements) without any reduction in the therapeutic effects of levodopa on motor function. On the contrary, nabilone actually prolonged the effect of levodopa by 76%. Cannabinoid receptors are the receptors for marijuana, called also cannabis; they are concentrated mainly in the basal ganglia of the brain, which control movement. Cannabinoid receptor agonists could be a novel approach to motor complications induced by dopaminergic therapy in Parkinson�s disease.
Fox et al. Mov Disord 2002; 17: 1180-1187
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